FIG A1.

Model-predicted treatment outcomes of radiotherapy (RT) alone, RT after surgical resection (SR), and RT before surgical resection (RS) for tumors of 10⁸ viable cancer cells pretreatment and increasing number of treatment fractions in a cohort of virtual patients with different combinations of tumor growth rate (r) and immune recruitment rate (f) in response to tumor burden. Radiation is delivered to total doses of 50, 60, and 70 Gy in 25, 30, and 35 daily fractions at 2 Gy per day, 5 days per week. Tumor control (TC) by treatment (blue) and progressive disease (PD; red) refer to tumor eradication and escape after treatment, respectively. For all simulations, we set RT-induced antitumor immunity to q = 4.5 × 10⁻¹ day⁻¹.