FIG A5.
Model-predicted treatment outcomes of radiotherapy (RT) alone, RT after surgical resection (SR), and RT before surgical resection (RS) for tumors of 108 viable cancer cells pretreatment and increasing surviving fractions of tumor cells at 2 Gy (SF2) in a cohort of virtual patients with different combinations of tumor growth rate (r) and immune recruitment rate (f) in response to tumor burden. Radiation is delivered to a total dose of 50 Gy in 25 daily fractions at 2 Gy per day, 5 days per week. Tumor control (TC) by treatment (blue) and progressive disease (PD; red) refer to tumor eradication and escape after treatment, respectively. For all simulations, we set RT-induced antitumor immunity to q = 4.5 × 10−1 day−1.