Skip to main content
. Author manuscript; available in PMC: 2019 Jul 28.
Published in final edited form as: Interv Cardiol Clin. 2016 Jun 21;5(3):307–320. doi: 10.1016/j.iccl.2016.02.007

Figure 6.

Figure 6

Receptor mediated sustained tissue retention. In vivo coating absorption (A) and local tissue pharmacokinetics (B–D) of a fast eluting O3FA DES. The O3FA coating quickly elutes off the stent with low accumulation in arterial tissue (A). This results in faster release of Corolimus from O3FA DES (red) compared to Sirolimus release from Cypher Select Plus DES (green) in the same cohort (B). Yet in vivo tissue contents (symbols) for both DES are comparable tissue levels up to 56 days post implantation and closely predicted by a computational model that accounts for high affinity drug binding to FKBP12 (lines). The inset illustrates that modeling that does not account for high affinity drug binding to FKBP12 (dashes) predicts unrealistically fast tissue clearance.(D) Model predicted FKBP12 saturation by Corolimus (red line) correlates linearly with in vivo coating absorption (insert). Panels A–C reproduced with permission from(20).