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. Author manuscript; available in PMC: 2019 Sep 27.
Published in final edited form as: Nature. 2019 Mar 27;568(7752):410–414. doi: 10.1038/s41586-019-1062-1

Extended Data Figure 2. Functional surfaceome analysis identified SDC1 as a KRAS*-dependent surface candidate.

Extended Data Figure 2.

a, Normalized counts showing the distribution of reference and tumor barcodes to establish library coverage in vivo in three independent iKras p53L/+ tumor cells cultures, which show similar results. In vivo screens were conducted in 3-5 mice for for each cell culture.

b, Correlation matrix among replicates of orthotopic xenograft-derived AK192, AK196, and AK10965 tumors screened with the surfacome-targeting shRNA library (barcode level fold-change comparison, Pearson correlation coefficient).

c, Positive (Psma, Rpl30) and negative (Luc) controls were plotted applying the RSP/LogP score.

d, Venn diagram shows the number of hits identified from three independent iKras p53L/+ tumor cell cultures.