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. 2019 Jul 27;19:738. doi: 10.1186/s12885-019-5951-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Inhibition of miR-21 reduced colony formation and cell migration in breast cancer. a Colony-formation assay for Hs578T and MDA-MB-231 cells transfected with miR-21 inhibitor or non-targeted control (NT). The number of colonies was determined after 14 days. b Fold changes in colony number in the absence and presence of inhibitor were compared in three independent experiments. c Wound healing assay in Hs578T and MDA-MB-231 cells transfected with miR-21 inhibitor (40× magnification). d The relative wound closure was calculated after the experiments were performed in triplicate. e Transwell assay in Hs578T and MDA-MB-231 cells transfected with miR-21 inhibitor (100× magnification). f The relative migration of cells was determined after the experiments were performed in triplicate (*p < 0.05, **p < 0.01, ***p < 0.001)