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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Trends Biochem Sci. 2018 Dec 15;44(3):241–257. doi: 10.1016/j.tibs.2018.11.008

Figure 1. Peptide Staple Examples.

Figure 1

A (non-exhaustive) representation of several reported peptide staples is shown. All examples are drawn as i,i+4 staples except E which is shown as i,i+7, a more common stapling position for that staple type. A. Lactam bridge. B. Disulfide bridge. C. Bis-alkylation of cysteine residues. D. Ring-closing olefin metathesis of O-allylserine residues. E. All-hydrocarbon staple via ring-closing metathesis of α, α-disubstituted non-natural amino acids with all-hydrocarbon side chains. F. Double-click stabilization of azido non-natural amino acids.