Fig. 1.

Effects of a high-cholesterol (HC) diet in wild-type (WT) and Ppara-null mice. a Effects of HC diet on total cholesterol (TC) content in the liver and b in serum induced in WT (+/+) and Ppara-null (−/−) mice. c Effect on triglyceride (TG) content in liver. d Photo-micrographs of liver sections stained with hematoxylin and eosin. Arrow indicates inflammatory cell infiltration, suggesting steatohepatitis. Scale bar = 100 μm. e Effect on serum level of ALT. f Effect on serum tissue factor (TF) concentration, g effects on plasma carboxypeptidase B2 (CPB2), and h plasminogen activator inhibitor-1 (PAI-1). Black bars indicate control groups and white bars indicate HC diet-fed groups. Values are mean ± SD (n = 6 for each group). Data were compared between two groups using two-way ANOVA. Significant differences are indicated by *p < 0.05 and **p < 0.01