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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Biochim Biophys Acta Proteins Proteom. 2019 Jun 10;1867(10):954–960. doi: 10.1016/j.bbapap.2019.05.010

Figure 3:

Figure 3:

The details of repeat regions in CsgA amino acid sequence. The full length CsgA comprises of N-22 peptide sequence and five repeat units (R1-R5). The Gln residues at position 49 and 139 and Asn residues at position 54, 144 (all highlighted in cyan) are essential for CsgA amyloid assembly. The “gatekeeper residues” in regions R2, R3 and R4 (encircled in violet) prevent spontaneous aggregation. The conserved amino acids across repeat units are boxed together.