Table 5.
Percentage difference1 in creatinine-corrected concentrations (μg/g creatinine) of select EDC biomarkers by baseline characteristics among SELF participants
| 2,4-dichlorophenol |
2,5-dichlorophenol |
Benzophenone-3 |
Triclocarban |
Triclosan |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Characteristic | Unadj. pct. diff. | Adj. pct. diff. | Adj. 95 CI | Unadj. pct. diff. | Adj. pct. diff. | Adj. 95 CI | Unadj. pct. diff. | Adj. pct. diff. | Adj. 95 CI | Unadj. pct. diff. | Adj. pct. diff. | Adj. 95 CI | Unadj. pct. diff. | Adj. pct. diff. | Adj. 95 CI |
| Age (yrs) | |||||||||||||||
| 23–25 | 12.9 | 10.8 | (−10.1, 36.6) | 35.5 | 22.7 | (−12.3, 71.9) | −15.1 | −1.8 | (−31.1, 39.9) | 121.3 | 93.2 | (14.2, 226.8) | −7.2 | −3.8 | (−31.8, 35.8) |
| 26–28 | −0.4 | 1.3 | (−17.0, 23.6) | 10.8 | 6.3 | (−22.9, 46.6) | 3.5 | 24.5 | (−11.2, 74.6) | 38 | 21.8 | (−26.5, 101.8) | −13.9 | −3.3 | (−30.4, 34.4) |
| 29–31 | −5.9 | −4.1 | (−20.6, 16.0) | 4.1 | 5.1 | (−22.6, 42.6) | −11.4 | 0 | (−27.5, 37.8) | 52.2 | 16.9 | (−27.5, 88.4) | −21.1 | −19.3 | (−40.9, 10.3) |
| 32–35 | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference |
| Season of urine collection | |||||||||||||||
| Spring (March, April, May) | −6.5 | −3.3 | (−21.9, 19.8) | −24.7 | −20 | (−43.3, 12.8) | −2.5 | −14.9 | (−40.7, 22.2) | 104.1 | 126.6 | (33.3, 285.2) | 0.4 | −6.9 | (−34.5, 32.4) |
| Summer (June, July, August) | 4 | 5.8 | (−13.0, 28.6) | 10.7 | 14.4 | (−16.5, 56.6) | 36.9 | 25.4 | (−9.9, 74.5) | 9.2 | 15.9 | (−28.7, 88.3) | −16.6 | −20.9 | (−42.7, 9.1) |
| Autumn (September, October, November) | 1.9 | 5.3 | (−13.8, 28.6) | 6.2 | 8 | (−21.7, 48.9) | −17.6 | −20.5 | (−43.3, 11.5) | 17.9 | 23.4 | (−25.6, 104.8) | −29 | −26.2 | (−46.9, 2.6) |
| Winter (December, January, February) | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference |
| Marital status | |||||||||||||||
| Never married | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference |
| Currently married | −12.5 | −12.3 | (−26.2, 4.1) | −33 | −25.3 | (−43.3, −1.5) | 14.3 | 9 | (−18.5, 45.8) | −45.2 | −35.8 | (−58.2, −1.3) | 16.3 | 1.9 | (−23.2, 35.2) |
| Previously married | 2.1 | 3.7 | (−15.2, 26.9) | −19 | −14.2 | (−38.0, 18.7) | 7.8 | 9.3 | (−22.3, 53.8) | −12.5 | 7.1 | (−35.8, 78.6) | 23.2 | 20.3 | (−13.7, 67.7) |
| Education | |||||||||||||||
| ≤High school diploma/GED | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference |
| Some college/Associates/Technical | 26.7 | 20.8 | (−0.1, 46.0) | 0.9 | 14.1 | (−15.9, 54.8) | 77.4 | 28.2 | (−7.0, 76.7) | −40.8 | −27.1 | (−54.8, 17.6) | 129.4 | 56.5 | (14.5, 113.9) |
| ≥Bachelors degree | 21.2 | 6.6 | (−17.1, 37.0) | −11.5 | 6.4 | (−28.9, 59.4) | 220 | 77.2 | (15.8, 171.1) | −69.8 | −45.5 | (−71.0, 2.5) | 234.6 | 61.5 | (6.8, 144.1) |
| Household income | |||||||||||||||
| <$20,000 | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference |
| $20,000–$50,000 | 12.1 | 12.6 | (−4.6, 32.9) | −14.5 | −6.5 | (−28.4, 22.1) | 54.8 | 1.7 | (−23.2, 34.7) | −31.2 | 1.9 | (−32.9, 54.9) | 90.7 | 40.5 | (7.0, 84.6) |
| >$50,000 | 15.7 | 18.7 | (−6.0, 49.7) | −25.2 | −16.2 | (−42.3, 21.9) | 120.9 | 4.3 | (−29.6, 54.6) | −74.3 | −46.6 | (−70.2, −4.3) | 168.6 | 71.1 | (16.7, 151.0) |
| Smoking status | |||||||||||||||
| Never | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference |
| Past | 15.8 | 27.6 | (−1.1, 64.6) | 36.9 | 36.9 | (−9.1, 106.1) | −46.2 | −37.7 | (−59.5, −4.1) | 75.8 | 31.3 | (−30.2, 148.2) | −26.3 | −3.4 | (−36.5, 46.9) |
| Current | −14.6 | −4.4 | (−21.7, 16.8) | 1 6.4 | 14.8 | (−16.8, 58.4) | −56.1 | −35.6 | (−54.1, −9.6) | 41.2 | −5.2 | (−42.8, 57.2) | −63.3 | −41.2 | (−57.7, −18.2) |
| Alcohol use within the last year | |||||||||||||||
| None | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference |
| 1–5 drinks/day or ≥4 drinks once per month or less | −8.8 | −15.2 | (−27.9, −0.2) | −14 | −19.7 | (−38.1, 4.2) | 23.1 | 1.4 | (−22.9, 33.4) | −47.8 | −40.1 | (−60.1, −10.0) | 8.9 | −8.8 | (−30.2, 19.1) |
| ≥6 drinks/day or ≥4 drinks twice per month or more | −8.8 | −10.5 | (−26.9, 9.6) | 8.8 | −5.1 | (−31.5, 31.5) | −12.3 | 5.6 | (−25.0, 48.7) | −6.6 | −20.8 | (−52.4, 31.8) | −33.2 | −17 | (−40.5, 15.8) |
| Body mass index (kg/m2) | |||||||||||||||
| <25.0 | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference |
| 25.0–29.9 | −1.1 | 2.5 | (−17.0, 26.7) | 7.1 | 14.9 | (−18.2, 61.5) | 4.9 | −2.4 | (−31.8, 39.5) | 76.2 | 97.5 | (16.1,236.1) | 14.3 | 12.8 | (−20.3, 59.8) |
| 30.0–34.9 | −0.2 | 5.7 | (−15.1,31.6) | 13.3 | 29.9 | (−8.7, 84.8) | 30.2 | 23 | (−15.2, 78.2) | 28 | 54.7 | (−10.9, 168.5) | 2.8 | −0.1 | (−30.4, 43.4) |
| ≥35.0 | −7 | 1 | (−16.8, 22.5) | 4.4 | 13.8 | (−16.6, 55.3) | 8 | 21.4 | (−12.4, 68.4) | 233.4 | 221.7 | (98.0, 422.8) | −5.8 | 8.9 | (−20.8, 49.6) |
| Age at menarche | |||||||||||||||
| ≤10 | −12.2 | −8.7 | (−26.0, 12.6) | −19.1 | −17.9 | (−41.4, 15.0) | 36.5 | 54.4 | (8.3, 120.1) | 20.7 | −6 | (−44.4, 58.9) | 21 | 35.8 | (−3.9, 91.7) |
| 11 | −1.7 | −0.4 | (−18.0, 21.0) | −13.1 | −12.9 | (−36.3, 19.1) | 27.4 | 18.5 | (−14.7, 64.6) | 39.8 | 28.8 | (−20.9, 109.7) | 43.4 | 41.6 | (2.8, 94.9) |
| 12 | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference |
| 13 | 14.3 | 16.9 | (−4.7, 43.5) | 27.3 | 29.7 | (−6.7, 80.4) | 39.2 | 50.7 | (6.6, 113.1) | −1.5 | 7.8 | (−35.6, 80.4) | 5.4 | 9.9 | (−21.5, 54.0) |
| ≥14 | 11.7 | 14.2 | (−7.0, 40.2) | −2.5 | 0.4 | (−27.8, 39.7) | −8.7 | 3.1 | (−27.1, 46.0) | −17.5 | −16.3 | (−50.1, 40.4) | 32.8 | 39.9 | (−0.2, 96.2) |
| Parity (births) | |||||||||||||||
| 0 | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference |
| 1 | −16.3 | −12 | (−26.2, 4.8) | −14.7 | −6.4 | (−29.4, 24.1) | −37.2 | −28.6 | (−47.0, −4.0) | 1.4 | 6.4 | (−31.6, 65.7) | −25.3 | −21.1 | (−40.9, 5.3) |
| 2 | −17 | −11.3 | (−28.3, 9.8) | −28.1 | −22 | (−44.6, 9.9) | −36.5 | −28.7 | (−50.3, 2.3) | −8.8 | −2.6 | (−43.0, 66.5) | −32.2 | −22.4 | (−45.3, 10.3) |
| ≥3 | −24.8 | −17.9 | (−34.0, 2.2) | −14 | −5.2 | (−33.2, 34.7) | −42.1 | −20.8 | (−45.2, 14.6) | 18.7 | 15 | (−33.7, 99.4) | −56.6 | −44.9 | (−61.5, −21.1) |
| Sunscreen use | |||||||||||||||
| Never/hardly ever | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference | 0 | 0 | Reference |
| Sometimes | 14.1 | 8.1 | (−11.7, 32.4) | 6 | 15.4 | (−16.7, 59.9) | 147.8 | 104.2 | (45.0, 187.7) | −14.4 | 25.4 | (−24.9, 109.4) | 62.1 | 15 | (−17.6, 60.5) |
| Often/always | 10.9 | 7.1 | (−13.7, 33.0) | 24.3 | 41.7 | (0.0, 100.8) | 302.5 | 223.3 | (124.2, 366.5) | −27.4 | 2.5 | (−40.7. 77.1) | 49.7 | 2.4 | (−28.3, 46.3) |
1
Unadj models are bivariate models with each correlate modeled separately. Adj. models are adjusted for all correlates.