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. Author manuscript; available in PMC: 2019 Jul 29.
Published in final edited form as: Hippocampus. 2015 Oct 1;26(1):110–117. doi: 10.1002/hipo.22495

Figure 3:

Figure 3:

E2 recruits GluN2B-containing NMDARs and ERK signaling in induction of LTP at TA synapses. A1, A2) Plots show that blocking GluN2B-containing receptors using Ro25–6981 (RO; 1μM) and ERK activation using U0126 (20μM) significantly decreases the LTP magnitude in slices from E2-treated OVX rats (RO: E, n=10slices/8animals; E+RO, n=9slices/8animals; U0126: E, n=10slices/7animals; E+U0126, n=7slices/7animals). B1,B2, Plots show that blocking GluN2B-containing NMDARs using Ro25–6981 (RO; 1μM) or ERK activation using U0126 (20μM) does not alter the LTP magnitude in slices from vehicle-treated OVX rats (RO: V, n=8slices/8animals; V+RO, n=9slices/8animals; U0126: V, n=7slices/7animals; V+U0126; n=7slices/7animals). Insets, box plots show the summarized LTP data for each group. Error bars: SEM. Two sample t test, * denotes p < 0.05.