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. 2019 Jul 4;17:551–562. doi: 10.1016/j.omtn.2019.06.019

Figure 1.

Figure 1

circNrxn2 Acted an Endogenous miR-103 Sponge and Increased FGF10 Expression in Mice Adipose Tissue

(A) Scheme of the interaction of circNrxn2 and miR-103. (B) Scheme of the interaction of miR-103 and FGF10. (C) Double luciferase assay was performed. (D) qRT-PCR was used to detected circNrxn2 and GAPDH levels after streptavidin capture. (E) The expression of FGF10 in WAT of HFD mice (8-week-old C57BL/6J mice fed with an HFD for 10 weeks; inguinal WAT (iWAT) was acquired for these experiments). (F) The expression of circNrxn2, miR-103, and FGF10 in iWAT of HFD mice. (G–I) The expressions of circNrxn2 (G), miR-103 (H), and FGF10 (I) in iWAT of HFD mice after circNrxn2, miR-103, or FGF10 treatment. Data represent the mean ± SEM. *p < 0.05; **p < 0.01. n ≥ 3.