Table 2.
Subgroups analysis for the association between metastasis and the studied MCTs.
| Variable | MCT1 | MCT4 | ||||||
|---|---|---|---|---|---|---|---|---|
| Studies | Model (I2%) | HR [95% CI] | P | Studies | Model (I2%) | HR [95% CI] | P | |
| LNM | ||||||||
| Sample size | ||||||||
| <150 | 2 | R (83) | 1.22 [0.39, 3.89] | 0.73 | 5 | R (56) | 3.26 [1.48, 7.19] | 0.003 |
| ≥150 | 2 | R (86) | 2.93 [0.28, 30.16] | 0.37 | 3 | F (0) | 1.09 [0.76, 1.56] | 0.66 |
| Cancer type | ||||||||
| Breast cancer | 1 | R (N/A) | 0.67 [0.33, 1.38] | 0.28 | 1 | R (N/A) | 0.92 [0.31, 2.74] | 0.89 |
| CRC | - | - | - | - | 2 | R (68) | 1.64 [0.72, 3.71] | 0.24 |
| Other types | 3 | R (72) | 2.31 [0.85, 6.30] | 0.10 | 5 | R (73) | 2.69 [1.05, 6.92] | 0.04 |
| Quality score | ||||||||
| ≥7 | 4 | R (77) | 1.65 [0.68, 3.98] | 0.26 | 7 | R (63) | 1.74 [1.04, 2.91] | 0.04 |
| <7 | - | - | - | - | 1 | R (N/A) | 16.66 [0.88, 315.27] | 0.06 |
| DM | ||||||||
| Sample size | ||||||||
| <150 | 1 | R (N/A) | 20.64 [2.58, 164.89] | <0.001 | 4 | F (0) | 4.67 [2.27, 9.63] | <0.001 |
| ≥150 | 3 | R (87) | 1.42 [0.22, 9.02] | 0.71 | 6 | F (41) | 1.88 [1.40, 2.54] | <0.001 |
| Cancer type | ||||||||
| CRC | 1 | R (N/A) | 0.27 [0.11, 0.65] | 0.003 | 2 | F (0) | 3.38 [1.92, 5.96] | <0.001 |
| HCC | - | - | - | - | 3 | F (0) | 1.78 [1.20, 2.65] | 0.004 |
| Other types | 3 | R (77) | 7.31 [0.79, 67.51] | 0.08 | 5 | R (65) | 2.79 [0.87, 8.99] | 0.09 |
| Quality score | ||||||||
| ≥7 | 3 | R (90) | 1.67 [0.25, 11.33] | 0.60 | 7 | R (55) | 2.57 [1.40, 4.70] | 0.002 |
| <7 | 1 | R (N/A) | 24.17 [1.39,419.06] | 0.03 | 3 | F (0) | 1.76 [1.11, 2.79] | 0.02 |
CRC, colorectal cancer; DM, distant metastasis; F, fixed; HCC, hepatocellular carcinoma; LMN, lymph node metastasis; MCT, monocarboxylate transporter; N/A, not applicable; R, random.