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. 2019 Jul 17;9(7):e028287. doi: 10.1136/bmjopen-2018-028287

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Trial treatment for phase I study of pembrolizumab in combination with Bacillus Calmette-Guérin for patients with high risk non-muscle invasive bladder cancer. ^*The first three subjects will be dosed at 100 mg. If the Data Safety Review Team approves, the dose will be escalated to 200 mg when the fourth subject is enrolled. ^†The MK-3475 dosing interval may be increased due to toxicity. BCG treatment may be interrupted or delayed as per the instructions for use supplied with BCG. ^‡BCG: one phial of BCG suspended in 50 mL preservative-free saline.