Table 8.
Adjusted time to event Cox Proportional Hazards Models for RRDI Predicting Incidence of CVD Event Stratified by Gender for Continuous RRDI and across Categories of Participants with RRDI more than 20 dips/hour.
| Males (n=300) | Females (n=269) | P value | |
| Age, mean (SD) | 58 (8) | 58 (8) | 0.52 |
| Body mass index, kg/m2, mean (SD) | 30 (5) | 32 (7) | 0.0001 |
| AHI, mean (SD) | 13 (16) | 10 (12) | 0.0045 |
| RRDI (SLEEP), mean (SD) | 26 (24) | 18 (21) | <0.0001 |
| RRDI (ALL), mean (SD) | 30 (23) | 22 (20) | <0.0001 |
| RRDI (SLEEP)>20, n (%) | 143 (48) | 78 (29) | <0.0001 |
| RRDI (ALL)>20, n (%) | 179 (60) | 105 (39) | <0.0001 |
| Adjusted model (3)* (95% CI) p value | Adjusted model (3) * (95% CI) p value | ||
| Continuous RRDI (SLEEP) (10-unit increment) |
1.19 (1.04 to 1.36)
0.011 |
1.22 (0.96 to 1.54) 0.109 |
|
| RRDI category | |||
| <20 | REF | REF | |
| >20 | 1.85 (0.67 to 5.07) 0.234 |
1.29 (0.22 to 7.47) 0.779 |
|
| Continuous RRDI (ALL) (10-unit increment) |
1.22 (1.06 to 1.40)
0.006 |
1.25 (0.97 to 1.67) 0.086 |
|
| RRDI category | |||
| <20 | REF | REF | |
| >20 |
4.34 (1.32 to 14.34)
0.016 |
2.03 (0.38 to 10.77) 0.407 |
|
*Model adjusted for age, body mass index and AHI 4% categories.
AHI 4%, apnoea–hypopnoea index with hypopnoea scored if associated with at least 4% desaturation (events/hour); RRDI, R-R interval dips index (dips/hour).