Table 3.

Univariate logistic regression showing significant predictors of ACS in patients with chest pain

Variables	Total cohort (n=2773)
	OR (95% CI)	P value
Age	1.00 (0.99 to 1.02)	0.476
Gender	1.33 (1.04 to 1.71)	0.027
Diabetes	1.02 (0.78 to 1.31)	0.890
Hypertension	1.36 (1.07 to 1.73)	0.012
Current smoker	1.66 (1.29 to 2.11)	<0.001
TG*	1.40 (1.15 to 1.70)	<0.001
TC*	5.17 (3.30 to 8.15)	<0.001
HDL-C*	0.44 (0.30 to 0.66)	<0.001
LDL-C*	3.14 (2.37 to 4.17)	<0.001
ApoA1*	0.17 (0.09 to 0.29)	<0.001
ApoB*	2.83 (2.05 to 4.01)	<0.001
ApoE*	0.93 (0.76 to 1.17)	0.534
Lp(a)*	1.10 (1.00 to 1.21)	0.055
NTproBNP*	1.73 (1.61 to 1.88)	<0.001
CRP*	1.74 (1.59 to 1.90)	<0.001
hs-cTnT*	2.45 (2.24 to 2.70)	<0.001
Cer(d18:1/16:0)*	7.53 (5.11 to 11.17)	<0.001
Cer(d18:1/18:0)*	4.67 (3.55 to 6.17)	<0.001
Cer(d18:1/24:0)*	1.41 (1.05 to 1.90)	0.025
Cer(d18:1/24:1(15Z))*	5.09 (3.79 to 6.87)	<0.001
Cer(d18:1/14:0)*	2.04 (1.59 to 2.62)	<0.001
Cer(d18:1/20:0)*	4.55 (3.35 to 6.22)	<0.001
Cer(d18:1/22:0)*	2.36 (1.75 to 3.18)	<0.001
Cer(d18:0/16:0)*	2.02 (1.61 to 2.55)	<0.001
Cer(d18:0/18:0)*	2.26 (1.92 to 2.66)	<0.001
Cer(d18:0/24:0)*	1.49 (1.21 to 1.84)	<0.001
Cer(d18:0/24:1(15Z))*	2.73 (2.24 to 3.33)	<0.001
Cer(d18:1/24:1)*	1.57 (1.26 to 1.96)	<0.001
Cer(d18:1/16:0)/Cer(d18:1/24:0)*	4.11 (2.87 to 5.89)	<0.001
Cer(d18:1/18:0)/Cer(d18:1/24:0)*	3.84 (2.93 to 5.05)	<0.001
Cer(d18:1/24:1(15Z))/Cer(d18:1/24:0)*	2.63 (2.08 to 3.34)	<0.001

Data are OR (95% CI).

*Log transformed before analysis.

ACS, acute coronary syndrome; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoE, apolipoprotein E; Cer, ceramides; CRP, C reactive protein; HDL-C, high-density lipoprotein cholesterol; hs-cTnT, high-sensitivity cardiac troponin T; LDL-C, low-density lipoprotein cholesterol; LP(a), lipoprotein(a); NTproBNP, N-terminal pro-brain natriuretic peptide; TC, total cholesterol; TG, triglyceride.