Table 4.

Multivariable logistic regression showing significant predictors of ACS in patients with chest pain after adjustment for conventional risk factors

Baseline variables	Model 1	Model 2	Model 3	Model 4	Model 5
Hypertension	1.37 (1.03 to 1.83)*	—	1.35 (0.98 to 1.87)	1.41 (1.06 to 1.90)*	1.40 (1.01 to 1.96)*
Current smoker	1.93 (1.43 to 2.58)***	—	1.52 (1.09 to 2.10)*	1.99 (1.47 to 2.69)***	1.58 (1.12 to 2.21)**
LDL-C†	2.63 (1.91 to 3.64)***	—	2.01 (1.42 to 2.87)***	2.13 (1.51 to 3.04)***	1.64 (1.12 to 2.41)*
CRP†	1.40 (1.27 to 1.55)***	—	1.20 (1.07 to 1.34)**	1.38 (1.25 to 1.53)***	1.16 (1.03 to 1.31)*
NTproBNP†	1.63 (1.49 to 1.78)***	—	1.16 (1.04 to 1.29)**	1.57 (1.44 to 1.72)***	1.07 (0.95 to 1.19)
hs-cTnT†	—	2.45 (2.24 to 2.70)***	2.02 (1.80 to 2.27)***	—	2.19 (1.94 to 2.49)***
Cer(d18:1/24:1(15Z))/ Cer(d18:1/24:0)†	—	—	—	2.96 (2.16 to 4.07)***	4.46 (3.11 to 6.40)***
Cer(d18:1/14:0)†	—	—	—	1.44 (1.01 to 2.06)*	1.74 (1.17 to 2.61)**
Cer(d18:1/22:0)†	—	—	—	2.08 (1.32 to 3.29)**	2.30 (1.37 to 3.87)**

Data are OR (95% CI).

Model 1. Included traditional risk factors (hypertension, current smoker, LDL-C, CRP and NTproBNP levels).

Model 2. Only Included hs-cTnT.

Model 3. Included traditional risk factors and hs-cTnT.

Model 4. Included traditional risk factors and ceramides.

Model 5. Included traditional risk factors, hs-cTnT and ceramides.

*P<0.05, **p<0.01, ***p<0.001.

†Log transformed before analysis.

ACS, acute coronary syndrome; Cer, ceramides; CRP, C reactive protein; hs-cTnT, high-sensitivity cardiac troponin T; LDL-C, low-density lipoprotein cholesterol; NTproBNP, N-terminal pro-brain natriuretic peptide.