Table 5.

Discrimination and reclassification of ACS with various multivariable logistic regression models

Old model	New model	AUC (95% CI)	P value-AUC	NRI (95% CI)	P value-NRI
Traditional factors*	-	0.78 (0.75 to 0.81)	-	-	-
hs-cTnT	-	0.80 (0.77 to 0.83)	-	-	-
Traditional factors*	+hs-cTnT	0.81 (0.78 to 0.84)	0.220	0.52 (0.40 to 0.64)	<0.001
Traditional factors*	+Ceramides†	0.81 (0.78 to 0.84)	<0.001	0.35 (0.23 to 0.47)	<0.001
Traditional factors* +hs-cTnT	+Ceramides†	0.87 (0.84 to 0.89)	<0.001	0.51 (0.39 to 0.64)	<0.001

P values AUC and p values NRI are for the difference between old models and new models. Bold used to highlight those p values <0.05.

*Traditional risk factors include hypertension, current smoker, LDL-C, CRP and NTproBNP levels.

†Ceramides include Cer(d18:1/24:1(15Z))/Cer(d18:1/24:0), Cer(d18:1/14:0) and Cer(d18:1/22:0).

LDL-C, CRP, NT-proBNP, hs-cTnT and ceramides levels are log transformed before analysis.

ACS, acute coronary syndrome; CRP, C reactive protein; hs-cTnT, high-sensitivity cardiac troponin T; LDL-C, low-density lipoprotein cholesterol; NT-proBNP, N-terminal pro-brain natriuretic peptide.