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. 2019 Jul 16;5(7):1120–1136. doi: 10.1021/acscentsci.9b00397

Scheme 11. Steroid Carrier Protein (SCP) 2L as a Host Protein for the Hydroformylation of Long-Chain Alkenes.

Scheme 11

(a) Sequential (bio)conjugation of maleimide derivative 15, phosphines 16–18, and rhodium to assemble the final artificial hydroformylases. (b) The hydroformylation of 1-octene by Rh(acac)-18∼15·SCP-2L A100C yields preferentially linear nonanal. (c) Crystal structure of SCP-2L with Triton X-100 bound in the hydrophobic tunnel (PDB 1IKT) with the positioning of engineered cysteine residues for bioconjugation at either opening shown. The authors hypothesize that the hydrophobic channel forces the insertion of the CO at the terminal position of the alkene, resulting in the linear aldehyde.