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. Author manuscript; available in PMC: 2019 Dec 26.
Published in final edited form as: Nature. 2019 Jun 26;571(7765):413–418. doi: 10.1038/s41586-019-1347-4

Figure 1. Distinct structural classes of FOXA1 aberrations.

Figure 1

a) FOXA1 mutations and key alterations in mCRPC. Mutations in ETS, AR, WNT, PI3K, DNA repair (DRD) were aggregated at the pathway/group level. b) Locus-level recurrence of RNA-seq structural variations (SVs). c) Structural classification of FOXA1 mutations. TAD, transactivation domain; Forkhead, Forkhead DNA-binding domain; RD, regulatory domain d) Structural classification of FOXA1 locus rearrangements. Dups, Tandem duplications; Tlocs, translocations; Invs, inversions; Dels, deletions. e) Frequency of FOXA1 mutational classes by PCa stage (n=888 primary, 658 metastatic) (two-sided Fisher’s exact test; tFET). f) Variant allele frequency by stage and class (two-sided t-test). Boxplot center: median, box: Q1/Q3, whiskers: Q1/Q3±1.5xIQR. g) Locus-level recurrence of SVs based on RNA-seq by PCa stage (tFET). h) Integrated (RNA-seq and WES) recurrence of FOXA1 alterations classes in mCRPC (SU2C-MCTP, n=370).