Table 2.
Change in Primary Outcome Measures by Treatment Group
| AP-treated | RC | NP | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable (units) | Week 0 | Week 16 | Δ (SD), [CI] | Cohen's d | Week 0 | Week 16 | Δ (SD), [CI] | Cohen's d | Week 0 | Week 16 | Δ (SD), [CI] | Cohen's d | Main effect of treatment group |
| Primary outcome variables | |||||||||||||
| DEXA total fat (kg) | 33.37 (17.99) | 32.94 (19.99) | −0.43 (3.13) [−2.16 to 1.31] | −0.14 | 30.51 (5.33) | 31.27 (4.62) | 0.76 (2.05) [−1.39 to 2.91] | 0.37 | 37.76 (11.56) | 34.96 (11.84) | −2.79 (3.35) [−4.52 to −1.07] | −0.83 | F[2,34] = 4.81, p = 0.01a |
| PDFF (%) | 6.71 (8.97) | 6.30 (7.22) | −0.41 (4.95) [−3.55 to 2.73] | −0.08 | 13.26 (7.77) | 12.64 (7.52) | −0.62 (1.57) [−2.26 to 1.02] | −0.39 | 5.66 (9.44) | 3.91 (5.13) | −1.75 (4.93) [−4.38 to 0.87] | −0.35 | F[2,30] = 3.60, p = 0.04b |
| CIMT (cm) | 0.0439 (0.0075) | 0.0471 (0.0079) | 0.0032 (0.0098) [−0.0038 to 0.0101] | 0.33 | 0.0481 (0.0052) | 0.0467 (0.0054) | −0.0014 (0.0045) [−0.0061 to 0.0033] | −0.31 | 0.0497 (0.0070) | 0.0501 (0.0083) | 0.0004 (0.0064) [−0.0029 to 0.0037] | 0.06 | F[2,29] = 0.37, p = 0.70 |
a
p = 0.03, RC vs NP.
b
p = 0.04, RC vs NP.
AP-treated, antipsychotic-treated youth undergoing weekly weight loss treatment; CI, confidence interval; CIMT, carotid intima media thickness; DEXA, dual-energy X-ray absorptiometry; NP, nonpsychiatric youth undergoing weekly weight loss treatment; RC, antipsychotic-treated youth undergoing monthly recommended care; SD, standard deviation.