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Effects of SETD1 or EZH2 gene knockdown on cell function and gene expression. (A) Relative mRNA expression of COL1A1, COL3A1, and RUNX2 genes after knockdown of EZH2 and KDM6B. (B) ALP activity in PDLSCs after knockdown of KDM6B or EZH2 gene. (C) Relative mRNA expression of CCL5, IL-1β, and DEFA4 genes after knockdown of SETD1B and KDM5B. (D) Cell migration analysis of human PDLSCs challenged with LPS after knockdown of SETD1B or EZH2. PDLSC, periodontal ligament stem cell.
