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. 2019 Jul 25;28(15):1026–1036. doi: 10.1089/scd.2019.0027

FIG. 2.

FIG. 2.

miR-200c reduces protein level of proinflammatory and osteoclastogenic mediators after LPS stimulation. (A–E) Relative fold change of transcripts of IL-6 (A), IL-8 (B), p50 (C), p65 (D), and IFRD1 (E) in HGFs with different transfections 24 h after stimulation with 1 μg/mL of LPS-PG. *P < 0.05 versus HGFs untreated with LPS; #P < 0.05 versus LPS-EV; performed in replicate. (F) Targetscan.org predicted the possible binding site of miR-200c-p3 and the 3′UTR of IFRD1 at the position 1,120–1,126. IFRD1, interferon-related developmental regulator-1; LPS-PG, Porphyromonas gingivalis lipopolysaccharide.