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miR-200c reduces both inflammatory and osteoclastogenic mediators in vivo. (A) Fold change of miR-200c in gingival tissue of rats 4 or 7 days after receiving PEI-miR-200c at 1 or 10 μg and controls. (B–D) Relative fold change of transcripts of IL-6 (B), IL-8 (C), IFRD1 (D), and the ratio of RANKL/OPG (E) at gingival tissues of rats 1 week after receiving different treatments under LPS-PG challenge at 10 μg. *P < 0.05 versus untreated; #P < 0.05 versus EV; n = 3 for each treatment.
