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AIPs induce ER‐mediated apoptosis by disturbing potassium homoeostasis. Proposed mechanism for ER stress‐mediated apoptosis driven by the perturbation of potassium homeostasis. AIPs reduce the intracellular potassium ion levels, resulting in strong activation of the unfolded protein response (UPR) in the ER. The stressed ER leads to oxidative conditions by overproducing ROS, thereby damaging the mitochondria and activating apoptosis signaling.
