Table 1.

Summary of selected pharmacokinetic data of statins1,8,10,15,56,87

	Simvastatin	Lovastatin	Atorvastatin	Pravastatin	Rosuvastatin	Fluvastatin	Pitavastatin
Pro-drug	Yes	Yes	No	No	No	No	No
Bioavailability (%)	<5	<5	12–14	17–18	20	24	51
Half-life (hours)	2–5	1.3–5	13–16	1–3	20	0.5–3	11
Protein binding (%)	>95	>95	80–99	43–55	88	>90	96
Hepatic extraction (%)	83	≥70	70	45	63	>68	>60
Renal excretion (%)	13	10	<5	20	10	5	15
CYP450 metabolism and isoenzyme	CYP3A4	CYP3A4	CYP3A4	Clinically not relevant	CYP2C9 minimally	CYP2C9	CYP2C9 minimally