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. 2019 Jul 12;8(14):e011994. doi: 10.1161/JAHA.119.011994

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© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Stress accelerates cell proliferation and media elastic laminal degradation and collagen in cathepsin S wild‐type (CatS^+/+) mice. A and B, Representative proliferating cell nuclear antigen (PCNA) immunostaining images of media smooth muscle cell proliferation and combined quantitative data for PCNA ⁺ cells. C through F, Representative images and quantitative data for the number of broken elastin fragments (Elastica van Gieson) and collagen content (picrosirius red [PSR]). Bar=100 μm. The results are mean±SEM (n=5–6). ***P<0.001 vs CatS^+/+ group by Student t test.