Table 8.
Relations of TOD to the Incidence of CVD and Mortality (Composite Outcome)
| TOD | No. of Participants | No. of Events | HR (95% CI) | |||
|---|---|---|---|---|---|---|
| Models Adjusted For | Only Covariates | Covariates+CPP | Covariates+MAP | Covariates+PWV | ||
| No. of TODs | ||||||
| 0 | 5026 | 347 | Referent | Referent | Referent | Referent |
| ≥1 | 777 | 154 | 1.31 (1.06–1.61)* | 1.25 (1.02–1.54)* | 1.30 (1.05–1.60)* | 1.30 (1.06–1.60)* |
| % Attenuation of effect size for ≥1 TOD upon adjustment for arterial stiffness measure | 0.0 (referent) | 16.7 | 3.5 | 2.9 | ||
| No. of TODs | ||||||
| 0 | 5026 | 347 | Referent | Referent | Referent | Referent |
| 1 | 709 | 125 | 1.23 (0.99–1.53) | 1.20 (0.96–1.49) | 1.22 (0.98–1.52) | 1.22 (0.99–1.52) |
| 2 | 68 | 29 | 1.92 (1.28–2.88)† | 1.65 (1.08–2.51)* | 1.88 (1.25–2.84)† | 1.87 (1.24–2.82)† |
| P for trend | 0.002 | 0.013 | 0.003 | 0.002 | ||
| % Attenuation of effect size for TOD upon adjustment for arterial stiffness measure | ||||||
| 1 TOD | Referent | 12.5 | 2.3 | 2.0 | ||
| 2 TOD | Referent | 23.2 | 3.1 | 3.5 | ||
Hazard ratios (HRs) are adjusted for age, sex, body mass index, diabetes mellitus, antihypertensive treatment, smoking, total cholesterol/high‐density lipoprotein cholesterol ratio, triglycerides, lipid‐lowering medications, heart rate, and estimated glomerular filtration rate. CPP indicates central pulse pressure; CVD, cardiovascular disease; MAP, mean arterial pressure; PWV, pulse wave velocity; TOD, target organ damage.
*P<0.05; † P<0.01.