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. 2019 Jul 9;8(14):e011852. doi: 10.1161/JAHA.118.011852

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© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Associations between metabolomic measures and carotid intima‐media thickness (cIMT) in children and adults. Association measures are difference in mean cIMT per 1‐SD unit increase in metabolite for A) CheckPoint children (blue), CheckPoint adults (red), and B) The Avon Longitudinal Study of Parents and Children (ALSPAC) mothers (gray) adjusted for age and sex. Error bars represent 95% confidence intervals (CI). Significant associations after P values adjusted for multiple testing using the Benjamini–Hochberg procedure are shown in bold (false discovery rate=0.10). CHPT indicates Child Health CheckPoint; HDL, high‐density lipoprotein; IDL, intermediate‐density lipoprotein; LDL, low‐density lipoprotein; VLDL, very‐low‐density lipoprotein.