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. 2019 Jul 22;12:2237–2242. doi: 10.2147/IDR.S181906

Figure 3.

Figure 3

Screening for PPK1-His6-tag inhibitors. Inhibitors of E. coli PPK1 activity were selected by measuring polyP production using DAPI fluorescence. Evaluated molecules (1 μM) were previously assayed toward PPK1 from P. aeruginosa PAO1 (PaPPK1).8 These compounds were selected by virtual screening for inhibitors of PPK1 and for antivirulence activity toward P. aeruginosa PAO1.