Figure 5.).
A. Murine model of DSS-induced colitis and ethanol. A 2% DSS concentration was administered ad libitum in drinking water for 5 days to mimic symptoms of UC. On day 5, DSS was discontinued to allow entrance into UC remission. A binge alcohol paradigm was employed where mice were gavaged with alcohol or water on days 5, 6, and 7. Mice were further subdivided and were gavaged with either 1 × 105 CFUs C. rodentium or water 3 hours post last gavage on day 7. Mice were euthanized on day 11.
B. Ethanol decreased % survival following C. rodentium infection. n=7–8 animals/group.