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. 2019 Jun 27;8(13):e012609. doi: 10.1161/JAHA.119.012609

Figure 5.

Figure 5

Impaired glucose tolerance and dysregulated liver metabolites in microRNA (miR)‐33 knock out knock in (KOKI) mice. A, Glucose and insulin tolerance of miR‐33 wild‐type (WT) and miR‐33 KOKI mice. n=6 for WT, and n=5 for KOKI. *P<0.05 compared with WT. B, Number of significantly dysregulated metabolites for miR‐33 knockout mice compared with WT and miR‐33b KI mice compared with WT mice. n=6 for each. *P<0.05 compared with knockout (tested by Fisher's exact test). C, Significantly dysregulated pathways in miR‐33b KI mice liver. Horizontal bars in the line chart or dot plots indicate mean±SEM. AMPK indicates AMP kinase; AUC, area under the curve; FDR, false discovery rate; IPGTT, intraperitoneal glucose tolerance test; IPITT, intraperitoneal insulin tolerance test; KO, Knock out.