Table 4.
Results of MR Using Continuous Genetic Scoresa With Interaction Between HGS and BMI
| Outcome | HR Per Unit Increase in HGS At the Median BMI | HR Per Unit Increase in BMI at the Median HGS | Interaction Term (HR) | Interaction P Value |
|---|---|---|---|---|
| Fatal/non‐fatal CVD | 1.02 (0.97–1.08) | 1.04 (1.00–1.07) | 0.97 (0.89–1.05) | 0.434 |
| CVD mortality | 0.88 (0.75–1.02) | 1.03 (0.94–1.13) | 1.12 (0.89–1.40) | 0.344 |
| All‐cause mortality | 0.86 (0.79–0.94) | 1.00 (0.96–1.06) | 1.08 (0.95–1.22) | 0.239 |
BMI indicates body mass index; CVD, cardiovascular disease; HGS, hand‐grip strength; HR, hazard ratio; WHR, waist‐hip‐ratio.
a
Genetic risk score derived from internal weights.