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. 2019 Jun 26;8(13):e012272. doi: 10.1161/JAHA.119.012272

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© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Forest plot showing changes in functional capacity including (A) NYHA functional class, (B) 6MWD following ARNI, and (C) changes of NYHA functional class comparing ARNI with ACEIs/ARBs. 6MWD indicates 6‐minute walking distance; ACEI, angiotensin‐converting enzyme inhibitor; ARB, angiotensin receptor blocker; ARNI, angiotensin‐receptor neprilysin inhibitor; df, degrees of freedom; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; IV, intravenous; NYHA, New York Heart Association.