Table 1.
Composition and characterization of VPN-loaded lipid-based NCs
| Nanocarrier type | Composition | PS (nm) | PDI | ZP (mV) | EE (%) | |
|---|---|---|---|---|---|---|
| Ingredients | Level | |||||
| SLNs | GMS (%) | 5 | 386±27 | 0.481 | −3.16±1.45 | 89.01 |
| Surfactant (%) | 1 | |||||
| Surfactant HLB | 11.1 | |||||
| TFs | VPN: PC (molar ratio) | 1:4.8 | 590±47 | 0.444 | 1.89±1.01 | 97.34 |
| PC: Surfactant (%) | 95:5 | |||||
| Surfactant HLB | 4.3 | |||||
| Peg-Lips | Hydrogenated PC (%) | 1.5 | 205±73 | 0.494 | −52.27±0.80 | 59.05 |
| Cholesterol (%) | 0.25 | |||||
| DCP (%) | 0.3 | |||||
| PEG 4000 (%) | 0.25 | |||||
| TPGS-micelles | TPGS (%) | 2 | 13±2 | 0.484 | −2.79±0.35 | 100 |
Notes: All NCs contain the same concentration of VPN (0.25%). Span and Tween were used as non-ionic surfactant.
Abbreviations: SLNs, solid lipid nanoparticles; PEG, polyethylene glycol; GMS, glyceryl monostearate; VPN, vinpocetine; TPGS, D-α-tocopherol polyethylene glycol 1000 succinate; PS, particle size; ZP, zeta potential; EE, entrapment efficiency; DCP, dicetyl phosphate; PC, phosphatidylcholine.