TABLE 2.
Pharmacokinetic parameters of amoxicillin at different concentrations for twice daily administration.
| Parameters | 5 mg/kg (n = 5) | 10 mg/kg (n = 5) | 20 mg/kg (n = 4) | 30 mg/kg (n = 4) |
| t1/2ka (h) | 3.999 ± 0.001 | 3.614 ± 0.028 | 3.342 ± 0.081 | 3.547 ± 0.106 |
| t1/2 (h) | 4.265 ± 0.012 | 3.964 ± 0.015 | 4.230 ± 0.011 | 3.863 ± 0.065 |
| Tmax (h) | 5.957 ± 0.140 | 5.459 ± 0.132 | 5.412 ± 0.139 | 5.338 ± 0.044 |
| Cmax (μg/mL) | 0.285 ± 0.094 | 1.247 ± 0.160 | 3.478 ± 0.028 | 4.783 ± 0.127 |
| AUC0–12 h (μg⋅h/mL) | 1.393 ± 0.134 | 5.544 ± 0.028 | 12.419 ± 0.024 | 19.606 ± 0.075 |
The t1/2ka, t1/2, Tmax, Cmax, and AUC0–12h were the mean values of multiple dose; n, represents the number of animals per group.