TABLE 3.
Pharmacokinetic parameters of amoxicillin at different concentrations for once daily administration.
| Parameters | 5 mg/kg (n = 5) | 10 mg/kg (n = 5) | 20 mg/kg (n = 5) | 30 mg/kg (n = 4) |
| t1/2ka (h) | 3.859 ± 0.012 | 3.465 ± 0.033 | 2.413 ± 0.102 | 2.528 ± 0.013 |
| t1/2 (h) | 4.184 ± 0.008 | 4.407 ± 0.017 | 5.874 ± 0.020 | 4.871 ± 0.002 |
| Tmax (h) | 5.796 ± 0.023 | 5.624 ± 0.075 | 5.256 ± 0.073 | 4.974 ± 0.521 |
| Cmax (μg/mL) | 0.198 ± 0.016 | 0.960 ± 0.021 | 2.832 ± 0.142 | 3.906 ± 0.072 |
| AUC0–24 h (μg⋅h/mL) | 1.916 ± 0.113 | 7.863 ± 0.013 | 18.140 ± 0.090 | 29.421 ± 0.570 |
The t1/2ka, t1/2, Tmax, Cmax and AUC0–24h were the mean values of multiple dose; n, represents the number of animals per group.