Figure 1.

Plasma concentration–time profiles and pharmacokinetic parameters of pravastatin in healthy volunteers following administration of pravastatin plus placebo and pravastatin plus cyclosporin A (CsA). (a) Pravastatin plasma concentration–time profile in each treatment group (mean ± SEM); (b) pravastatin area under the concentration–time curve from time of administration up to the time of the last quantifiable concentration (AUC _{0–last(0–12 hour)}); and (c) peak plasma concentration (C_max) of each individual in the pravastatin plus placebo and pravastatin plus CsA group.