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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Gastroenterology. 2019 Apr 15;157(2):492–506.e2. doi: 10.1053/j.gastro.2019.04.013

Figure 5. The esophageal inflammatory niche recruits SCJ progenitor cells.

Figure 5.

(A) CXCR2 expression in BE in L2-IL1B mice on HFD and in L2-IL1B/IL8Tg mice and germfree L2-IL1B mice (n=4–8). GSEAs for (B) a mouse epithelial (cancer) stem cells gene signatures comparing L2-IL1B HFD vs. L2-IL1B Chow and L2-IL1B/IL8Tg vs. L2-IL1B Chow or a (C) human migratory cancer cell gene signature. (D) ISH for Lgr5+ progenitor cells at the SCJ in the BE region in L2-IL-1B mice on HFD and in L2-IL1B/IL8Tg mice compared to germfree L2-IL1B mice (n=5–7). (E) ISH show co-expression of Lgr5+ (brown) and CXCR2 (red) progenitor cells. (F) Crypt fission in L2-IL1B HFD mice and L2-IL1B/IL8Tg mice. Data are represented as mean ± SEM (*p<0.05). L2=L2-IL-1β, L2/IL8Tg=L2-IL-1β/IL8Tg, HFD=High fat diet.