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The Nrf2 system. Nrf2 activation elicits enhanced de novo GSH synthesis, detoxification of ROS and xenobiotics, enhancement of the thioredoxin (TXN) antioxidant system, regeneration of NAPDH, and heme metabolism.
Adapted from Tonelli C, Chio IIC, Tuveson DA. Transcriptional Regulation by Nrf2. Antioxid Redox Signal. 2018;29(17):1727–1745; with permission.
