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. Author manuscript; available in PMC: 2020 Jul 25.
Published in final edited form as: Cell. 2019 Jul 25;178(3):612–623.e12. doi: 10.1016/j.cell.2019.06.035

Figure 2.

Figure 2.

Overall structure of the T.el4h group II intron. (A) A segmented low-pass filtered map of the group II intron in the pre-1r state is shown with DVI (red), the maturase protein (yellow), the target DNA (purple), and rest of the RNA (blue) highlighted. The structural model of T.el4h in the pre-1r state is also shown. Domains II-VI of the RNA are labeled DII to DVI and the maturase is labeled RT. DVI (boxed) adopts a downward conformation before DNA integration. RNA secondary structure diagrams show only the core domains of the pre-1r and pre-2r states. These diagrams approximate the domain organization evident from the cryo-EM structures. Intron RNA domains are labeled with Roman numerals and important tertiary interactions are indicated by Greek letters. (B) Similar segmented low-pass filtered map of the group II intron retroelement complex in the pre-2r state. The structural model indicates a 90° swinging of DVI.