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. Author manuscript; available in PMC: 2019 Jul 29.
Published in final edited form as: Cell Rep. 2019 Jul 16;28(3):640–654.e6. doi: 10.1016/j.celrep.2019.06.053

Figure 5. Synaptic Silencing of mPFC→PER Pathway Abolished Sequence Memory.

Figure 5.

(A) Guide cannulas into the PER.

(B) Locations of PER infusion cannulas in all rats (n = 10).

(C) Schematic representation of mPFC hM4Di fiber density in PER (restricted to region of interest).

(D) In the hM4Di+ group, SMI significantly differed between the Veh and CNO conditions for all three repeated conditions. No differences between Veh and CNO were detected in the mCherry-only group.

(E) Individual rat performance in each repeated condition for both groups.

(F) In the hM4Di+ group, there was no significant relationship between repeated conditions and infusions.

(G) ISI was not significantly different between PER Veh and CNO conditions for either group.

(H) IOI was not significantly different between PER Veh and CNO infusions for either group.

(I) InSeqcorrect and OutSeqcorrect nose-poke times were not significantly different between Veh and CNO conditions in the hM4Di+ and mCherry-only groups.

(J) hM4Di+ group nose-poke times show no obvious shifts in nose-poking behavior.

(K) hM4Di+ group nose-poke times show a decisional shift (indicated by a star) where the rats incorrectly identified OutSeq odors as InSeq.

All data are represented as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001; ns, not significant.