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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Pharmacol Res. 2019 May 6;145:104263. doi: 10.1016/j.phrs.2019.104263

Figure 23. Effect of olaparib on liver mitochondrial DNA integrity, mitochondrial DNA copy number and nuclear DNA integrity in aged male and female Balb/c mice subjected to CLP.

Figure 23.

(A): mitochondrial DNA integrity, mitochondrial DNA copy number and nuclear DNA integrity values (expressed as % of control) in aged male mice; (B): mitochondrial DNA integrity, mitochondrial DNA copy number and nuclear DNA integrity values (expressed as % of control) in aged female mice. Data are shown in sham mice (not subjected to CLP) (“Sham”), in vehicle-treated mice subjected to CLP for 24 hours (“CLP”) and in mice subjected to CLP in the presence of 10 mg/kg olaparib (“CLP Olaparib 10 mg/kg”). Data are shown as mean ± SEM of 10 animals for each group.