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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Pharmacol Res. 2019 May 6;145:104263. doi: 10.1016/j.phrs.2019.104263

Fig. 31. Effects of olaparib in septic shock: a working hypothesis.

Fig. 31.

Via inhibition of the catalytic activity of PARP, olaparib exerts cellular bioenergetic effects as well as pluripotent modulation of gene transcription. These effects lead to changes in the circulating and tissue-resident immune cell distribution, improve bacterial elimination, protect against multiorgan injury and eventually culminate in improved survival rate. These effects are dependent on gender and age of the animals. See the Discussion section for further context and explanation.