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. Author manuscript; available in PMC: 2019 Jul 29.
Published in final edited form as: Cell Rep. 2019 Jul 16;28(3):792–803.e4. doi: 10.1016/j.celrep.2019.06.044

Figure 1. MCs Controlled Systemic Energy Expenditure and SAT Thermogenesis and Browning in Mice on a Chow Diet.

Figure 1

(A and B) NE-stimulated mouse metabolic rate, including oxygen consumption (VO2; A) and carbon dioxide production (VCO2; B) in WT mice (n = 13), Kitw-sh/w-sh mice (n = 13), WT mice receiving saline (WT+Saline, n = 13) or DSCG (WT+DSCG, n = 16) intraperitoneal (i.p.) injections.

(C) Core body temperatures for the indicated groups of mice.

(D) UCP1 immunostaining of representative SAT sections (n = 8 per group); scale bars, 100 µm.

(E) Immunoblot analysis and quantification of UCP1 relative to β-actin in SAT (n = 6 per group).

(F) Real-time PCR analysis of thermogenic and mitochondrial genes in SAT (n = 8~13 per group).

Data are mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.