Table 5.
Hazard ratio (HR) with corresponding 95% confidence interval (CI) from univariate and multivariate analysis at time of surgery (n = 792).
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| HR (95%CI) | p | HR (95%CI) | p | |
| Gender | ||||
| Female | 1 | |||
| Male | 1.08 (0.84–1.37) | 0.564 | ||
| Age | ||||
| <16 years | 1 | 1 | ||
| ≥16 years | 1.53 (1.20–1.94) | <0.001 | 1.38 (1.08–1.77) | 0.010 |
| Origin | ||||
| Osseous | 1 | |||
| Extra-osseous | 1.23 (0.87–1.74) | 0.245 | ||
| Volume | ||||
| <200 ml | 1 | 1 | ||
| ≥200 ml | 1.65 (1.30–2.09) | <0.001 | 1.29 (0.99–1.66) | 0.053 |
| Location | ||||
| Extremity | 1 | 1 | ||
| Axial (excl pelvic) | 1.09 (0.82–1.43) | 0.564 | 1.05 (0.79–1.41) | 0.735 |
| Pelvic | 1.59 (1.18–2.15) | 0.002 | 1.30 (0.94–1.79) | 0.110 |
| Disease extent | ||||
| Localized | 1 | 1 | ||
| Pulmonary metastasis | 2.09 (1.55–2.81) | <0.001 | 1.99 (1.47–2.70) | <0.001 |
| Extrapulmonary metastasis | 2.88 (2.03–4.08) | <0.001 | 3.18 (2.23–4.53) | <0.001 |
| Number of metastatic lesions | ||||
| None | 1 | 1 | ||
| One | 1.52 (0.85–2.73) | 0.159 | 1.62 (0.90–2.92) | 0.108 |
| ≥2 | 2.54 (1.96–3.29) | <0.001 | 2.53 (1.93–3.32) | <0.001 |
| Margin status | ||||
| Wide | 1 | 1 | ||
| Marginal | 1.48 (1.08–2.03) | <0.001 | 1.06 (0.76–1.47) | 0.736 |
| Intralesional | 2.43 (1.55–3.81) | <0.001 | 1.47 (0.91–2.93) | 0.120 |
| Histological response | ||||
| 100% | 1 | 1 | ||
| 90–99% | 1.66 (1.22–2.25) | <0.001 | 1.58 (1.16–2.16) | 0.004 |
| <90% | 2.86 (2.15–3.81) | <0.001 | 2.90 (2.15–3.93) | <0.001 |
| Radiotherapy | ||||
| No | 1 | |||
| Pre-operative radiotherapy | 1.19 (0.71–1.99) | 0.503 | ||
| Post-operative radiotherapy | 1.10 (0.85–1.41) | 0.478 | ||