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. 2019 Jul 29;9:10981. doi: 10.1038/s41598-019-46481-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Marginal estimates of hippocampal subfield volumes (mm³) from immediate recall (IR) and delayed recall (DR) models, showing effects of IR, DR and age. (a) Upper panels present marginal estimates (blue line; light blue band ±95% CI) of subfield volumes as a function of IR score; overlaid cyan scatter presents observed participant-wise data. Lower panels present marginal estimates (±95% CI) of subfield volumes as a function of age (years), with participant-wise scatters. (b) Marginal estimates for DR model; all specifications as per (a). *IR/DR cubic term significant, p < 0.05; • age quadratic term significant, p < 0.05; grey shading denotes marginally significant trend - see Tables 2 and 3, and Results. Note differences in y-axis ranges across panel rows in (a,b); adjusted to accommodate differences in subfield volumes (see also Supplementary Fig. 2). All marginal estimates calculated from fully-adjusted models, holding all covariates at their means.