Table 2.
Marginal estimates (95% CI) of hippocampal subfield volumes across immediate recall (IR) and delayed recall (DR) scores, with age effects.
| IR model | DR model | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IR score: | 4 | 5.5 | 7 | 8.5 | 10 | DR score: | 0 | 2 | 4 | 6 | 8 | 10 |
| Subfield | Subfield | |||||||||||
| CA2/3 | 195.49 (185.20, 205.78) | 207.16 (203.13, 211.18) | 204.06 (201.50, 206.63) | 200.73 (197.38, 204.08) | 211.66 (202.54, 220.77) | CA2/3 | 188.04 (174.43, 201.65) | 200.8 (195.14, 206.47) | 205.34 (201.37, 209.31) | 205.04 (202.38, 207.71) | 203.29 (200.13, 206.45) | 203.46 (197.93, 208.98) |
| CA4 | 238.67 (229.76, 247.57) | 243.82 (240.32, 247.32) | 241.12 (238.91, 243.33) | 239.74 (236.83, 242.65) | 248.87 (240.98, 256.75) | CA4 | 230.99 (219.19, 242.78) | 240.38 (235.45, 245.32) | 242.66 (239.21, 246.11) | 241.53 (239.23, 243.83) | 240.74 (238.00, 243.47) | 243.99 (239.20, 248.79) |
| GC-DG | 280.82 (271.63, 290.02) | 285.54 (281.93, 289.15) | 281.68 (279.39, 283.96) | 279.33 (276.33, 282.33) | 288.60 (280.46, 296.75) | GC-DG | 271.76 (259.59, 283.94) | 283.00 (277.91, 288.08) | 284.94 (281.39, 288.50) | 282.40 (280.02, 284.77) | 280.16 (277.33, 282.98) | 283.02 (278.07, 287.96) |
| Presubic. | 288.56 (273.70, 303.43) | 287.26 (281.50, 293.03) | 288.11 (284.39, 291.82) | 289.78 (284.97, 294.59) | 290.96 (277.80, 304.13) | Presubic. | 295.39 (275.81, 314.98) | 291.75 (283.66, 299.85) | 288.18 (282.48, 293.87) | 286.29 (282.44, 290.15) | 287.73 (283.18, 292.28) | 294.11 (286.15, 302.07) |
| Subiculum | 414.46 (399.76, 429.17) | 413.52 (407.82, 419.22) | 409.18 (405.51, 412.86) | 406.40 (401.64, 411.16) | 410.14 (397.11, 423.16) | Subiculum | 408.75 (389.36, 428.15) | 413.08 (405.06, 421.10) | 412.39 (406.75, 418.04) | 409.54 (405.72, 413.35) | 407.34 (402.83, 411.84) | 408.62 (400.74, 416.51) |
| CA1 | 619.49 (599.14, 639.84) | 627.4 (619.55, 635.26) | 613.44 (608.35, 618.53) | 602.52 (595.96, 609.09) | 619.56 (601.54, 637.58) | CA1 | 597.09 (570.33, 623.86) | 624.97 (613.94, 636.00) | 626.67 (618.90, 634.45) | 615.56 (610.28, 620.84) | 605.00 (598.78, 611.22) | 608.34 (597.46, 619.22) |
| Mol. layer | 542.20 (527.64, 556.75) | 548.28 (542.64, 553.93) | 539.71 (536.07, 543.34) | 533.16 (528.45, 537.87) | 545.34 (532.45, 558.23) | Mol. layer | 530.88 (511.71, 550.06) | 547.18 (539.25, 555.11) | 547.65 (542.07, 553.23) | 540.66 (536.89, 544.44) | 534.60 (530.15, 539.06) | 537.84 (530.05, 545.64) |
| Hipp. tail | 486.84 (466.04, 507.63) | 493.39 (485.36, 501.42) | 493.91 (488.71, 499.12) | 490.03 (483.32, 496.74) | 483.37 (464.95, 501.78) | Hipp. tail | 493.85 (466.44, 521.25) | 489.65 (478.36, 500.94) | 489.94 (481.98, 497.90) | 492.04 (486.63, 497.44) | 493.25 (486.88, 499.62) | 490.89 (479.75, 502.03) |
| Parasubic. | 61.49 (49.21, 73.77) | 60.30 (55.52, 65.08) | 61.31 (58.25, 64.38) | 63.61 (59.63, 67.60) | 66.27 (55.40, 77.14) | Parasubic. | 63.61 (47.39, 79.83) | 60.82 (54.10, 67.54) | 59.93 (55.20, 64.65) | 60.70 (57.51, 63.88) | 62.90 (59.14, 66.67) | 66.31 (59.72, 72.90) |
| HATA | 57.72 (46.12, 69.32) | 59.32 (54.80, 63.84) | 61.47 (58.58, 64.36) | 63.30 (59.53, 67.06) | 63.90 (53.63, 74.18) | HATA | 53.68 (38.31, 69.04) | 58.51 (52.14, 64.89) | 60.34 (55.87, 64.82) | 60.96 (57.95, 63.97) | 62.16 (58.59, 65.72) | 65.73 (59.49, 71.97) |
| Fimbria | 81.84 (68.25, 95.43) | 78.32 (73.04, 83.59) | 79.52 (76.13, 82.92) | 83.13 (78.73, 87.53) | 86.80 (74.77, 98.83) | Fimbria | 73.35 (55.38, 91.33) | 78.69 (71.25, 86.13) | 80.03 (74.80, 85.26) | 79.93 (76.39, 83.46) | 80.95 (76.77, 85.13) | 85.66 (78.35, 92.97) |
| Age: | 50 | 60 | 70 | 80 | Age: | 50 | 60 | 70 | 80 | |||
| Subfield | Subfield | |||||||||||
| CA2/3 | 205.09 (194.55, 215.64) | 205.31 (201.88, 208.73) | 203.91 (201.42, 206.39) | 200.89 (196.27, 205.52) | CA2/3 | 205.13 (194.55, 215.71) | 205.07 (201.63, 208.50) | 203.84 (201.35, 206.33) | 201.45 (196.83, 206.07) | |||
| CA4 | 246.75 (237.61, 255.89) | 245.70 (242.71, 248.69) | 241.62 (239.48, 243.77) | 234.52 (230.47, 238.58) | CA4 | 246.94 (237.76, 256.12) | 245.47 (242.47, 248.47) | 241.53 (239.38, 243.68) | 235.11 (231.06, 239.17) | |||
| GC-DG | 293.64 (284.21, 303.08) | 290.25 (287.17, 293.32) | 281.93 (279.71, 284.15) | 268.69 (264.52, 272.86) | GC-DG | 294.22 (284.75, 303.69) | 290.09 (287.00, 293.18) | 281.78 (279.56, 284.01) | 269.29 (265.12, 273.46) | |||
| Presubic. | 298.04 (282.86, 313.23) | 296.96 (292.09, 301.83) | 288.95 (285.35, 292.55) | 274.00 (267.46, 280.55) | Presubic. | 298.35 (283.14, 313.56) | 297.20 (292.32, 302.07) | 288.95 (285.34, 292.55) | 273.61 (267.09, 280.13) | |||
| Subiculum | 413.04 (398.02, 428.07) | 420.32 (415.5, 425.14) | 411.42 (407.85, 414.98) | 386.33 (379.85, 392.8) | Subiculum | 413.46 (398.39, 428.52) | 420.14 (415.31, 424.97) | 411.29 (407.72, 414.86) | 386.92 (380.45, 393.38) | |||
| CA1 | 632.95 (612.19, 653.71) | 630.61 (623.99, 637.24) | 613.94 (609.00, 618.88) | 582.92 (574.05, 591.80) | CA1 | 634.80 (614.02, 655.58) | 630.20 (623.58, 636.82) | 613.49 (608.55, 618.43) | 584.67 (575.84, 593.51) | |||
| Mol. layer | 568.91 (554.04, 583.79) | 560.86 (556.08, 565.63) | 539.54 (536.02, 543.07) | 504.97 (498.56, 511.38) | Mol. layer | 570.11 (555.21, 585.00) | 560.68 (555.90, 565.45) | 539.28 (535.75, 542.81) | 505.91 (499.52, 512.30) | |||
| Hipp. tail | 517.47 (496.26, 538.69) | 515.56 (508.79, 522.33) | 492.92 (487.87, 497.97) | 449.54 (440.47, 458.61) | Hipp. tail | 515.70 (494.43, 536.97) | 515.02 (508.25, 521.80) | 493.11 (488.06, 498.17) | 449.97 (440.93, 459.02) | |||
| Parasubic. | 51.57 (39.01, 64.13) | 56.02 (51.97, 60.07) | 62.56 (59.59, 65.53) | 71.18 (65.73, 76.64) | Parasubic. | 51.61 (39.00, 64.21) | 56.10 (52.04, 60.16) | 62.57 (59.59, 65.55) | 71.02 (65.57, 76.47) | |||
| HATA | 56.46 (44.59, 68.33) | 58.44 (54.6, 62.28) | 61.80 (58.99, 64.61) | 66.55 (61.37, 71.72) | HATA | 56.46 (44.52, 68.40) | 58.42 (54.56, 62.27) | 61.80 (58.98, 64.61) | 66.60 (61.42, 71.77) | |||
| Fimbria | 77.78 (63.89, 91.67) | 82.05 (77.58, 86.51) | 81.75 (78.46, 85.04) | 76.88 (70.87, 82.88) | Fimbria | 78.50 (64.54, 92.46) | 82.17 (77.69, 86.65) | 81.64 (78.34, 84.95) | 76.93 (70.92, 82.93) | |||
Marginal estimates adjusted for sex, education, total brain grey matter volume, handedness, smoking, and cardiovascular disease history. Bold text - significant non-linear effects in fully-adjusted model
(p < 0.05); italicised text - marginal linear/non-linear coefficients in fully-adjusted model (p < 0.08); see Table 3. See Supplementary Tables 1 and 2 for IR and DR full model outputs, respectively.