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. 2019 Jul 29;9:10966. doi: 10.1038/s41598-019-47439-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Recurrently mutated genes in HER2-positive luminal B BC. Each column represents a case. The top panel shows tumor mutation burden. The middle panel shows MLH1 V384D germline mutation status: dark purple, mutant type; light purple, wild type. The bottom panel shows distribution of mutations. Four mutation types are distinguished by different colors. The right panel represents the mutation frequency in the 94 samples.