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. 2019 Jul 29;9:10918. doi: 10.1038/s41598-019-47382-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vitro RNAi screening experiments suggested six genes - CD27, CEACAM1, CTLA4, LRIG1, PDCD1LG2, and TNFRSF18 as tumor suppressors. Frequency histogram analysis showed that the shRNAs (short hairpin RNAs) targeting one of the six genes were ranked within the top 1% highly expressed shRNAs from the genome-scale library of ∼100,000 pooled shRNAs targeting about 17,080 genes. Plots of the last 21 cell lines for the genes - LRIG1, PDCD1LG2 (PD-L2), and TNFRSF18 were shown.