Table 1.
Information of the genes encoding the 31 T-cell coinhibitory/costimulatory molecules that were investigated in this study.
| Symbol | Entrez Gene Name | Type(s) |
|---|---|---|
| CTLA4 | cytotoxic T-lymphocyte associated protein 4 | transmembrane receptor |
| CD80 (B7-1) | CD80 molecule | transmembrane receptor |
| CD86 (B7-2) | CD86 molecule | transmembrane receptor |
| PDCD1 (PD-1) | programmed cell death 1 | phosphatase |
| CD274 (PD-L1) | CD274 molecule | enzyme |
| PDCD1LG2 (PD-L2) | programmed cell death 1 ligand 2 | enzyme |
| LAG3 | lymphocyte activating 3 | transmembrane receptor |
| CLEC4G (LSECtin) | C-type lectin domain family 4 member G | other |
| HAVCR2 (TIM3) | hepatitis A virus cellular receptor 2 | other |
| LGALS9 | galectin 9 | other |
| HMGB1 | high mobility group box 1 | transcription regulator |
| CEACAM1 | carcinoembryonic antigen related cell adhesion molecule 1 | transporter |
| TIGIT | T cell immunoreceptor with Ig and ITIM domains | other |
| PVR (CD155) | poliovirus receptor | other |
| PVRL2 (NECTIN2, CD112) | nectin cell adhesion molecule 2 | transmembrane receptor |
| VISTA (VSIR, C10orf54) | V-set immunoregulatory receptor | other |
| LRIG1 | leucine rich repeats and immunoglobulin like domains 1 | other |
| LRIG2 | leucine rich repeats and immunoglobulin like domains 2 | other |
| LRIG3 | leucine rich repeats and immunoglobulin like domains 3 | other |
| ICOS | inducible T cell costimulator | transmembrane receptor |
| ICOSLG | inducible T cell costimulator ligand | other |
| OX40 (TNFRSF4) | TNF receptor superfamily member 4 | transmembrane receptor |
| OX40L (TNFSF4) | TNF superfamily member 4 | cytokine |
| GITR (TNFRSF18) | TNF receptor superfamily member 18 | transmembrane receptor |
| GITRL (TNFSF18) | TNF superfamily member 18 | cytokine |
| 4-1BB (TNFRSF9) | TNF receptor superfamily member 9 | transmembrane receptor |
| 4-1BBL (TNFSF9) | TNF superfamily member 9 | cytokine |
| CD40 (TNFRSF5) | CD40 molecule | transmembrane receptor |
| CD40L (CD40LG, TNFSF5) | CD40 ligand | cytokine |
| CD27 (TNFRSF7) | CD27 molecule | transmembrane receptor |
| CD70 (TNFSF7) | CD70 molecule | cytokine |